What is Sibutramine?

Sibutramine Effects and Weight Loss

What is Sibutramine?

Sibutramine was approved by the FDA for the treatment of obesity in 1997. The FDA approved the anorexigenic drug Sibutramine as a short-term supplement to diet therapy and daily exercises.

Sibutramine was developed by the pharmaceutical company Abbott Laboratories as a drug for the treatment of depression. Results of the clinical studies have demonstrated that Sibutramine exerts the weak antidepressant effect; it does not provide clinically significant relief of depression symptoms.

In addition, the results of the clinical studies have shown that people who regularly take Sibutramine have noted the decrease of appetite. Additional studies have confirmed that Sibutramine helps suppress appetite and avoid the consumption of large amounts of food.

Important for Sibutramine

And it is also important that Sibutramine does not only suppress appetite but also stimulates thermogenesis. Therefore, weight loss occurs not only due to the reduction of daily ration caloric value, but and because of burning fat even with minimal physical activity.

What is Sibutramine Effectiveness?

Sibutramine effectiveness is confirmed by the long-term clinical studies. The clinical and post-marketing studies have shown that Sibutramine helps reduce weight by no less than 5 percent of the initial body weight.

How to use Sibutramine ro help weight loss rapidly?

In order to achieve rapid weight loss, the use of diet pills Sibutramine should be combined with a healthy diet and active lifestyle. It should be noted that a low-fat diet and exercises will help to maintain healthy weight even after discontinuation of Sibutramine administration.

Sibutramine Using

Due to the regular use of drug Sibutramine, the degree of abdominal obesity, waist and hips measurements significantly reduces. In addition, weight loss helps significantly improve the lipid profile and thereby reduce the risk of cardiovascular pathologies.

Tags: Sibutramine effects, Fitness, weight loss, weight loss drugs, sibutramine dosage

Advanced Parabolan Intermediate Dosage For Bodybuilding Beginners

Parabolan (Trenbolone Hexahydrobenzylcarbonate) For Bodybuilding

Parabolan (Trenbolone Hexahydrobenzylcarbonate) is one such anabolic steroid where appropriate Parabolan dosage needs to be clearly explained and properly emphasized. Trenbolone itself is an extremely powerful anabolic steroid, both in its potential anabolic properties in muscle tissue as well as in regards to its side effects and the dosage required to experience various negative side effects.

As previously explained, when determining the appropriate Parabolan dosage to administer for the purpose of performance and physique enhancement, the compound’s characteristics, properties, and strengths should always be taken into account. These properties therefore then become the determining factor in how much Parabolan should be used in general by most users. User types can be broken down into three different tiers: beginner, intermediate, and advanced. It should be noted, however, that Parabolan is considered an intermediate to advanced level anabolic steroid that is very rarely suited for beginners or newcomers to the anabolic steroid world. However, being that is the case, Parabolan among the users who are experienced enough to use it can be categorized into the three tiers of users among Trenbolone users themselves (not as general anabolic steroid users). Therefore, a Parabolan user should be an individual with sufficient experience and cycle experience to be able to confidently use a strong anabolic steroid such as Parabolan. It should also be noted that the definition of an advanced anabolic steroid user is not always an individual who utilizes obscenely high doses. Although this can be a characteristic, it is not the rule.

Beginner Parabolan doses normally land in the range of 152 – 220mg per week, which can range from half an ampoule to a full ampoule every week. Such a dose, especially for an individual who is new to Parabolan, should experience some impressive physique and performance changes when paired with an appropriate diet and training regimen. Intermediate users can find great gains with the same Parabolan dosage as a beginner, but can venture as high as 228 – 456mg per week, which is the equivalent of two ampoules per week. Experienced users have been known to venture higher than 500mg per week, although this Parabolan dosage is rarely necessary considering the strength of Trenbolone. Parablan is such a powerful hormone that excessive doses are not required, even for intermediate and advanced users who can most of the time still make excellent progress within the beginner Parabolan dose range. When it comes to a compound as strong as Trenbolone Hexahydrobenzylcarbonate, often times less is more when it comes to dosage.

*Referenced from Internet*

Tags: Anabolic steroids, Trenbolone, Parabolan, Trenbolone Hexahydrobenzyl Carbonate, steroids, steroid users, bodybuilding, parabolan dosage, tren, steroid intermediate, testosterone, steroid hormones, musclebuilding, muscle gains, beginner parabolan dosage, steroid raw powders

What is CJC-1295 Pepdite?

CJC-1295 Dosage for Bodybuilding

What is CJC-1295 Peptide?

CJC-1295 is an injectable peptide used to increase GH production. This peptide is a growth hormone releasing hormone (GHRH) mimetic, or analog. That is to say, it works in the same way as GHRH, and may be referred to as being a GHRH.

The principal use of CJC-1295 is to provide increased GH levels, which also results in increased IGF-1 levels. An increase in these levels can aid fat loss and in some instances can aid muscle gain as well. Generally, a product in the GHRH category, including CJC-1295, is chosen as an alternate to using GH, and only rarely is combined with GH.

The other principal GHRH product is Mod GRF 1-29, which in most instances I recommend over CJC-1295. The products differ in their duration of action. Mod GRF has an approximately-ideal short duration of action allowing pulsatile dosing, whereas CJC-1295 has an extended duration of action which prevents such dosing.

It’s important to avoid confusing CJC-1295 with “CJC-1295 w/o DAC.” The latter is not CJC-1295, but rather is misnamed Mod GRF. When a peptide doesn’t have DAC, it’s not CJC-1295.

CJC 1295 is sometimes marketed as “CJC-1295 with DAC.” This simply is CJC-1295.

Pharmacological class of CJC-1295

CJC-1295 is in the class of growth hormone releasing hormone (GHRH) mimetics. GHRH is also the name of the naturally-occurring hormone in the body, but the natural compound is not used in bodybuilding or as a performance-enhancing drug due to its high cost of manufacture and its extremely brief duration of action.. CJC-1295 is a modified version of the first 29 amino acids of GHRH, together with addition of a “Drug Affinity Complex” or DAC. The combination of modifications provides a half life of about 1 week, and steady blood levels after injection.

CJC-1295 amplifies GH production in the same way that GHRH does. Administration does not initiate a pulse of GH release. Because CJC-1295 provides steady blood levels, it increases the amplitude of natural GH pulses on an ongoing basis. It does not combine especially efficiently with a GHRP, because the DAC modification results in relatively lower ongoing levels of free peptide

How to use CJC-1295

CJC 1295 is typically provided in vials containing 2 or 5 mg of lyophylized powder, though the amount can vary. The contents should be reconstituted by adding a convenient amount of sterile or bacteriostatic water. If for example 2 mL is chosen and the dosing of the vial is 2 mg, the resulting solution then has a concentration of 1 mg/mL, or 1000 mcg/mL.

At time of dosing, an insulin syringe is used to draw and then inject the desired amount. In the above example, a 1000 mcg dose would require a volume of 1 mL, or “100 IU” as marked on an insulin syringe.

Injection may be subcutaneous, intramuscular, or intravenous according to personal preference. If desired, peptide solutions from other vials, such as a vial of a GHRP product, may also be drawn into the same syringe, if there is room. This reduces the total number of injections required.

When recommending CJC 1295, we ordinarily recommend a dosage of 1000 mcg at a time, twice per week.

Combined use of CJC-1295 and a GHRP

As with Mod GRF, CJC-1295 use can be combined with use of GHRP, but if using a GHRP, for superior results I recommend combining Mod GRF with it rather than CJC-1295.

The most important reason for this is observed results. The principal cause of it is that the DAC modification results in relatively lower levels of free peptide. In and of itself, this would be a bad thing, but it’s counterbalanced by the lower levels being sustained. However, if creating peaks with a GHRP, it’s more efficient to have higher levels of free GHRH peptide in, so to speak, “lock step” with those peaks. Mod GRF does this, while CJC-1925 does not.

If choosing CJC-1295 anyway to stack with a GHRP, dosing of the CJC-1295 remains as recommended above, while GHRP dosing will be typically 100 mcg at a time, or 50 mcg at a time if using hexarelin.

When to use CJC-1295

This product is most suited to instances where an individual wishes to inject infrequently and is seeking substantive support for GH production rather than a maximum or near-maximum increase. This is because the flat blood levels it provides do not match up well with pulsatile dosing, which is needed for greatest effect. The steady levels can provide very good support for natural GH pulses, however.

Relatively rarely, adverse side effects associated with excessive GH use, such as pain from nerve compression (such as carpal tunnel pain), excessive water retention, or reduced insulin sensitivity can occur from CJC-1295 use. The cause is stimulation of a greater amount of GH production than is suitable for the individual case. The solution is to discontinue use until the problem is resolved, and to reduce dosage when resuming use.

For ongoing support of GH production, at doses recommended below, CJC-1295 does not need to be cycled.

Conclusion

For maximal effect in increasing GH production, rather than CJC-1295 we recommend Mod GRF 1-29 in combination with a GHRP, but for support of natural GH production CJC-1295 can provide a convenient solution with injection frequency of only twice weekly. Many have been pleased with the results from CJC-1295 use in bodybuilding, performance enhancement, and “quality of life” applications.

Tags: Peptide, CJC-1295, CAS 863288-34-0, CJC-1295 Peptide, gh, human growth hormone, hormones, Anabolic steroids, Bodybuilding, performance enhancement drug, bodybuilding steroids, roids, roid raws, hgh, fitness, IGF-1, GHRP, Miscle gains, 

What is T3/Cytomel?

T3 / Cytomel For Bodybuilding

What’s T3? 

What’s T3? T3 (also called triiodothyronine, liothyronine, Cytomel) is a thyroid hormone drug fairly commonly used for fat loss, particularly in the context of anabolic steroid cycles. T3 is naturally produced in the body as a result of T4 (thyroxine) production by the thyroid. Oral administration of T3 can yield higher levels of serum T3 than would occur naturally, allowing faster fat loss and in some cases potentially greater GH production and greater anabolism.

What are The Dosage of T3?

There are two approaches to dosing T3:

In the first approach, the goal is to achieve an ongoing edge in fat loss or to help maintain a near-personally-ideal body composition. In this approach, T3 dosing is very low, preferably 12.5 mcg/day but in some cases as much as 25 mcg/day. At the lower end of this range, typically thyroid testing will show no detectable suppression even with prolonged use. At the higher end, moderate suppression is sometimes seen, but results are superior to when T3 is not taken, and the suppression reverses rapidly upon discontinuing T3 use.

In the second approach, the goal is to achieve a quite substantial increase in rate of fat loss, at the known cost of inducing thyroid suppression. Most preferably the dosage is about 50 mcg/day, but in some instances can be as high as 75 mcg/day. Such use is preferably not ongoing, but only for a limited period of time such as 8-12 weeks, though there’s no exact requirement for timeframe.

What’s the Dividing Dose of T3?

Because T3 has a short half-life, divided doses are preferable to a single dose, except where total daily dosing is small. For example, with a dosing of 12.5 mcg.day this would best be taken as a single dose in the morning, but with 50 mcg/day, dividing the daily amount into three or four doses would be better than taking the entire amount at one time.

What’s the Problem of Instability of T3?

The first thing to consider about dosing of T3 is that the drug itself has poor stability, resulting in loss of potency with time even with some tabletted pharmaceutical products, and liquid preparations are even more prone to loss of potency. Dosings given below refer to fully potent T3, as found with US-made or European pharmaceutical products still within expiration date. In many instances, other T3 products will contain less or even much less T3 than the label may indicate. For this reason, we recommend seeking out genuine pharmaceutical T3. Otherwise, dosing can be uncertain or deceptive. For example, a person might find “150 mcg” per day to be an appropriate dose for him when using a low-potency product, but an extreme overdose when using a full-potency product.

Side Effects of Excessive Dosage of T3

High dosage of T3, typically starting at about 75 mcg/day but in some cases not starting until about 100 mcg/day, can cause tachycardia (elevated heart rate) and muscle weakness, and can be catabolic or at the least reduce anabolism. High dose anabolic steroids, of course, tend to mask this latter effect. Very high levels of T3 are dangerous to the heart.

The Post-cycle Suppression of Natural Thyroid Production

After extended use of T3 at a suppressive dose, natural production is suppressed for some time after discontinuing T3 use. Generally the duration appears related to the length of use. In cases of brief usage there’s typically no noticeable period of low function post-cycle, but with extended cycles the duration of low function can be measured for as long as about six weeks in some cases.

The literature article “Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy” provides an example of difficulty that can be encountered in recovering good thyroid production after a long period of oral thyroid use. While in this study all the subjects did recover “normal” thyroid production, as also happens routinely in bodybuilding use, the “normal” that they ended up with was the rock-bottom end of the normal range, about 40 mcg/dL total serum T4 and about 80 ng/dL total serum T3. These are not levels one wants to be at, and are low enough that metabolism would be impaired.

Interaction of High Serum T3 with IGF-1

High levels of T3 reduce levels of IGF-1, which can reduce anabolic effectiveness of GH, but does not change fat-loss effectiveness of GH.

The effect of blunting GH effectiveness is particularly pronounced when T3 dosage is greater than 50 mcg/day, and seems unnoticeable if present at all at dosings such as 25 mcg/day.

This effect causes some to view T3 as relieving side effects of GH; actually, what is occurring is the T3 is making the same dose of GH produce less IGF-1 in the body than usual. It would be more efficient simply to reduce dose of GH to a personally-suitable level.

Conclusion

T3 is a very effective compound for aiding fat loss, but has serious side effects when overdosed. With proper care, it’s an easily-cycled compound. Because T3 has limited stability, it’s best sourced from quality pharmaceutical products, with a second choice being Third World generics or relatively-fresh powder which has been carefully measured. Liquid products can lose potency rapidly and therefore are not preferred.

Tags: Hormones, T3, Cytomel, triiodothyronine, liothyronine, T3 Na, T3 Dosage, T3 Side effects, IGF-1, T4, GH, Anabolic Steroids, Hormone drug, Fat loss, Steroids, Bodybuilding, T3 Diving dose, weight loss, fitness, Gym-lovers, Muscle Gains, Bodybuilders, gh, human growth hormone, roids, roid raws, T3 and HGH, 

Information of Trestolone Acetate (MENT)

Trestolone Acetate (MENT) CAS 6157-87-5

Trestolone Acetate (MENT)

Testosterone and its esters are widely used for androgen replacement therapy. Testosterone undergoes 5 alpha-reduction to dihydrotestosterone (DHT) in the prostate and other tissues leading to potentially undesirable consequences in adult males.

Trestolone or 7 alpha-methyl-19-nortestosterone (MENT) is a synthetic androgen that is ten times as potent as testosterone. MENT is not 5-alpha reduced to DHT. It inhibits gonadotrophin release, suppresses testosterone and sperm production. Yet, MENT provides adequate replacement therapy for most androgen-dependant functions. MENT has a faster metabolic clearance rate than testosterone and, in contrast to testosterone, MENT does not bind to sex hormone binding globulin (SHBG). MENT remains capable of aromatization (to 7-alpha-methyl-estradiol) preserving the benefits estrogen imparts on male physiology.

The Population Council has investigated MENT [specifically MENT Acetate (MENT Ac)] for long-term clinical use for contraceptive purposes and hormone replacement therapy. Initial trials suggest it may be an ideal candidate since it is a non-5-alpha reducible androgen and requires lower doses due to its significantly increased potency over testosterone.

Various forms of MENT in human pharmaceutical preparations and devices for contraception and hormone therapy, specifically MENT Ac implant and MENT transdermal gel and patch formulations, are currently under clinical investigation. MENT is absorbed transdermally up to three times the rate of testosterone – 17 methyl testosterone and 17-α methyl testosterone.

MENT, as a transdermal and/or intramuscular preparation, will have application in a wide range of indications beyond androgen replacement therapy and contraception, including, without limitation, primary hypogonadism, testicular failure, ASIH, baldness, sarcopenia, loss of bone mass, muscle wasting and cachexia, BPH, prostate cancer and of course, bodybuilding and sports performance enhancement.

Trestolone acetate is the chemical name of active ingredient in MENT. MENT is a registered trademark of Population Council, Inc. in the United States and/or other countries.

References

Sundaram K, Numar K. 7alpha-methyl-19-nortestosterone (MENT): the optimal androgen for male contraception and replacement therapy. Int J Androl. 2000;23 Suppl 2:13-5.

Anderson, Richard A., A. Michael Wallace, Naveed Sattar, Narender Kumar, and Kalyan Sundaram. “Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men,” Journal of Clinical Endocrinology and Metabolism 88(6): 2784–2793.

von Eckardstein, Sigrid, Gabriela Noe, Vivian Brache, Eberhard Nieschlag, Horacio Croxatto, Francisco Alvarez, Alfred Moo-Young, Irving Sivin, Narender Kumar, Margaret Small, and Kalyan Sundaram, Population Council International Committee for Contraception Research. “A clinical trial of 7-α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men,” Journal of Clinical Endocrinology and Metabolism 88(11): 5232–5239.

Tags: Bodybuilding, Steroids, Tresrolone, Trestolone Acetate, Anabolic Steroid, MENT, Testosterone, DHT, Fitness, Gym-lovers, Muscle Gains, Hormones, Roids, Acetate Steroids, Anabolism, Enhancing performance drug, Enhancing Performance  compounds,  AAS, AS Raws

Anabolic Steroid: MK-677 in Bodybuilding

Anabolic Steroid: Mk-677 CAS 159752-10-0

Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.

How it Works

Growth Hormone pulse intensity can be increased through 4 possible mechanisms:

Increasing GHRH (growth hormone releasing hormone) release.

Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.

Reducing somatostatin release (somatostatin turns off GH release).

Inhibiting of somatostatin receptor signaling.

Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.

Benefits

In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.

Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.

A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.

Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.

How can it help you?

Elevated growth hormone has literally endless list of benefits to the human body, why do you think everyone tries to get their hands on HGH? That's why Nutrobal (Mk-677) is so effective, it increases Growth Hormone and IGF-1 levels.

As the studies show, Nutrobal can be used for a number of reasons from growing muscle mass, to getting shredded. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with hgh cycles. In fact, by using nutrobal, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It's like using HGH without having to inject daily.

In a multitude of studies, Nutrobal (Mk-677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits:

Increased Fat Oxidation (fat loss).

Increased Muscle gains (lean mass).

Tightening up loose skin.

Healing old injuries.

Healing Bones, Tendons and Ligaments.

In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles. That's an amazing result, but injecting IGF-1 daily is painful, costly and frustrating. Now, there is an oral-only alternative.

 

Whatsapp: +8618948752730

Cycles

Here is an example of a Nutrobal + Cardarine + Andarine Cycle

Week	NutrobalMk-677	CardarineGW-501516	Anrdarine(S-4)	HCGenerate ES	N2Guard
1	25mgs/ED	20mgs/ED	25mgs/ED	5tabs/ED	5caps/ED
2	25mgs/ED	20mgs/ED	35mgs/ED	5tabs/ED	5caps/ED
3	25mgs/ED	20mgs/ED	35mgs/ED	5tabs/ED	5caps/ED
4	25mgs/ED	20mgs/ED	45mgs/ED	5tabs/ED	5caps/ED
5	25mgs/ED	20mgs/ED	45mgs/ED	5tabs/ED	5caps/ED
6	25mgs/ED	20mgs/ED	50mgs/ED	3tabs/ED	5caps/ED
7	25mgs/ED	20mgs/ED	50mgs/ED	3tabs/ED	5caps/ED
8	25mgs/ED	20mgs/ED	60mgs/ED	2tabs/ED	5caps/ED
9	25mgs/ED	20mgs/ED	60mgs/ED	2tabs/ED	5caps/ED
10	25mgs/ED	20mgs/ED	70mgs/ED	2tabs/ED	5caps/ED
NOTE: Only ramp up andarine if you have the dosing schedule and side effects schedule properly planned. Otherwise, stick to a lower dose. See this andarine (s4) dosing schedule. Glossary: ED = every day mgs = milligrams tabs = tablets caps = capsules

This is an amazing cutting stack with Cardarine and Andarine, which will help melt off the stubborn fat and increase your muscle mass.

Doses

Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but I don't see the need to overdo it.

Side Effects

Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.

Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.

Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you're prone to prolactin sides? If you get gynecomastia from taking trenbolone, you're prone to prolactin sides.

Medical

Nutrobal (Mk-677) was found to be very safe and, in fact, showed to reduce tumors in mice, which was hypothesized to be from an increased immune system response.

Tags: Steroids, MK-677, Anabolic Steroids, hgh, Anabolism, Human Growth Hormone, Bodybuilding, Muscle Gains, Fitness, Hormones, Steroid hormones, Roids, Steroid Raws,