2016年8月19日星期五

Clomiphene Citrate (Clomid)

Clomiphene citrate Cas:50-41-9



Clomid citrate is commonly the first medication that is pre­scribed for patients who are unable to ovulate on their own with unspecified infertility in combination with insemina­tion. Women who have normal fallopian tubes, regular 28 day cycles, and partners with a normal sperm count, but are still experiencing infertility, are termed as having ‘unspecified’ infertility. The pituitary gland regulates the amount of FSH (follicle stimulating hormone) and LH (leutenizing hormone) in the system. These two hormones play a key role in ovulation. The levels of these hormones determine when and how many eggs are developed and re­leased. LH is responsible for the further maturation and re­lease of the egg(s).


Clomid citrate is an anti-estrogen medication. This means that it tricks the pituitary gland into thinking that the levels of estrogen in the body are low, causing the pituitary gland to secrete additional FSH and LH. This increase of FSH and LH stimulates the development of the follicles which contain the egg(s). Clomid citrate is taken as a pill, and is generally pre­scribed as one (50mg) pill each day for 5 days in the beginning of the menstrual cycle (days 3-7). A mature follicle is usually found around day 12 of the cycle. If ovulation does not occur, the medication can be changed to reflect the patient’s needs. Ultrasound is the best way to determine the number and maturity of the follicles. Ovulation predictor kits can be used to measure if there has been a surge of LH mid-cycle, indicating ovulation has occurred. Ovula­tion occurs about 24-28 hours after the detection of the LH surge in the urine. Once ovulation has occurred, natural or artificial insemination is performed in an attempt to fertilize the egg(s) that have been produced.

         Clomiphene citrate CAS:50-41-9
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2016年8月18日星期四

Nandrolone Undecanoate CAS: 862-89-5



What is nandrolone undecanoate?

Nandrolone undecanoate is an anabolic steroid that in composition is very similar to nandrolone decanoate. The medicine is not intended for oral administration and it is available as oil based injection. This medicine is considered safe for use in women; however it is indicated to assess all the risks prior to commencing the therapy with it. Nandrolone undecanoate is used to stimulate weight gain following extensive surgery, severe trauma or chronic infection or any other cases that result in inadequate weight gain. It may also be used to increase the muscle mass caused by long-term treatment with corticosteroids and to reduce bone pain associated with osteoporosis. The increase in muscle mass and strength is due to water retention in tissues and joints. It is a drug that may be obtained also without prescription. However, it is recommended to first consult a physician in order to assess its safety and efficiency prior to commencing to use it. Follow the therapy with it exactly as prescribed. Increased doses may increase the incidence of adverse reactions.


Contraindications

·Nandrolone undecanoate is contraindicated in persons who have a known hypersensitivity to it or to any of its ingredients;

·Do not use nandrolone undecanoate during pregnancy due to the fact that it crosses the placenta and may cause harm to the fetus. If you are pregnant or intend to become pregnant while on therapy with nandrolone undecanoate, prevent your doctor right away and discontinue with the drug.

·It is contraindicated the use of nandrolone undecanoate if the patient is breastfeeding. It is excreted into breast milk and may harm the fetus. Nursing mothers are advised to stop the breastfeeding while using this drug.


Administration and dosage

As already mentioned above, nandrolone undecanoate is a drug that comes in form of injection. An injection of 2 ml is equal to 2 ampoules, because each ampoule contains 80.5mg of nandrolone decanoate in 1ml. Nandrolone undecanoate has a shorter life period than nandrolone decanoate. Follow the usage exactly as indicated. In order to obtain the desired results it is important to follow a diet high in proteins and calories. For any other information, patients are advised to get the necessary counseling by consulting a physician. The dose of nandrolone undecanoate is set individually considering the medical condition and tolerance to the drug. Therefore, to get the right prescription for your particular medical condition, contact a physician. Nandrolone undecanoate is mostly injected twice a week. The minimum dosage is 2 ml per week. As this medicine is mostly used by athletes, the weekly dosage of 4 ml is sufficient for achieving the desired results. Higher dosages increase the incidence of side effects. For women it is recommended a dose of 1 ml per week in order to avoid the virilization symptoms.

Prior to injection of nandrolone undecanoate visually inspect the vial in order to detect any particles or gloomy content.

 
Nandrolone Undecanoate CAS: 862-89-5
Important tips for the use of nandrolone undecanoate

·Prevent your doctor about all medicines you are taking daily, including prescription, non-prescription ones, herbal products, minerals and natural supplements. It is not recommended the concomitant administration of nandrolone undecanoate with the following medicines: oral anticoagulants, oral hypoglycemics, corticosteroids and enzyme inducing agents. For the full list of medicines that may interact with nandrolone undecanoate, contact your physician.

·Inform your doctor about all existing diseases you have, including heart problems, kidney and liver disorders and others medical conditions. Make regular tests in order to periodically assess and evaluate the safety and efficiency of the drug for the desired results.

·If any allergic reactions to the drug develop, report about them right away and discontinue with the drug.

·Do not use higher doses of nandrolone undecanoate than the ones indicated by a physician or pharmacist. You may overdose and experience such adverse events as confusion, nausea and vomiting, diarrhea, dizziness and others. If you accidentally took a higher dose of nandrolone undecanoate, report about it and seek prompt medical help and assistance.



Possible side effects with nandrolone undecanoate

Like most of medicines, nandrolone undecanoate may cause side effects when used in prescribed/indicated doses. It happens due to the fact that each person reacts in a different way to the medicine as others. As already mentioned, nandrolone undecanoate is very similar to the mechanism of action with nandrolone decanoate; however, its increased androgenic component helps the athlete achieve a good strength with few side effects. Therefore, patients respond well to the therapy with nandrolone undecanoate. Side effects are rare and occur mostly in sensitive persons’ or when high dosages of medicine are taken.

Possible side effects with nandrolone undecanoate are the following:

·Increased blood pressure (hypertension);

·Elevated cholesterol levels;

·Acne;

·Gynecomastia.

Generally, most of the enumerated adverse reactions disappear after discontinuation of therapy with nandrolone undecanoate. However, there is increased incidence of side effects with any anabolic steroid that may have serious impact on your overall health condition.

Other side effects with nandrolone undecanoate are the following:

·Oily skin

·Hoarseness and change in voice;

·Unusual hair loss or unusual hair growth on the face and body;

·Nausea and vomiting;

·Bone pain;

·Swelling of feet;

·Sore throat and/or fever;

·Unusual weight gain.


If you miss a dose

If you forgot to take an injection of nandrolone undecanoate, take it as soon as you remember. If it is already too late to take the skipped dose, leave it and return to your usual schedule. Do not take a double dose to make up for the skipped one. Try to not miss more than one dose a day in order to not decrease the effect of the drug. If you have any questions related to the use of nandrolone undecanoate ask a pharmacist or contact a physician.


Storage

It is recommended to keep nandrolone undecanoate in a clean and dry place at the room temperature below 30 degrees C. Store the drug away from the direct sunlight and heat. Also, try to not store the ampoules in the kitchen or in the bathroom near sink. Keep it out of the reach and sight of children. Do not store the medicine in the refrigerator in order to avoid freezing. Also, do not use expired medicine. Always check the expiry date on the bottom of the packaging.

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Oral Turinabol CAS: 2446-23-3


Oral-Turinabol (dehydrochloromethyltestosterone) is an oral anabolic steroid which is interesting principally for reasons other than its unexceptional performance. It can however meet some specific needs.

What Is Oral-Turinabol?

Oral Turinabol is, to some extent, enigmatic and prone to misunderstanding.

It is not simply a tablet version of injectable Turinabol, or an alkylated version of it. Nor, despite claims, is it an anabolic steroid developed specifically for doping. That claim results from confusion with mestanolone.

Structurally, it is Dianabol with an added chlorine at the -4 position, which has the predictable advantage of preventing aromatization.

Caution must be taken however when trying to arrive at conclusions about anabolic steroids from structure. Substituting an atom or chemical bond makes large changes to the entire shape rather than affecting only a single point. This can result in changes in properties beyond the predictable. An example would be if one tried to predict the properties of Dianabol from its structural relation to boldenone (they are the same except for the 19-methylation of Dianabol.) While the methylation does provide the predictable oral bioavailability, in actuality Dianabol’s other properties are such that one can’t reasonably call “oral boldenone.”

In the case of Oral Turinabol, due to the above structural relation to Dianabol it’s commonly called a dry version of it. Now if this were true though, one could tell no difference between using OT alone and using Dianabol plus aromatase inhibitor. There is considerable difference in practice however.

OT must be considered its own compound rather than simply as a dry Dianabol. That said, this popular description is not a bad first approximation. Simply be aware of its limitations.

History Of Oral Turinabol

Ordinarily in anabolic steroid profiles I don’t discuss history of the drugs, but here it’s worth making an exception.

OT received an East German patent in 1961 and was soon approved as a prescription drug. At the time, there was wide medical belief that anabolic steroids were useful for recovery from surgery, burns, or nearly any condition that caused substantial loss of bodyweight. Newly developed anabolic steroids were considered suitable even for women and children, as it was thought that synthetic modifications dissociated androgenic from anabolic effects.

In 1966, use of OT for athletic doping began. This drug became the principal cause of the obvious virilization of East German female athletes of the era, despite the theoretical belief in separation of effects. Women did not respond as the theories from rat testing had predicted.

Why did the East Germans choose this specific compound for athletic doping? The reason does not seem to be from superior performance to Western anabolic steroids, or from drug testing concerns. That did not become an issue until much later. And a particularly favorable side-effect profile seems unlikely as the reason, as no other anabolic steroid has such a thoroughly documented track record for adverse effect on health.

A key doping advantage of OT for the East Germans was that it was locally produced. This provided easy availability, economy, and secrecy. And it was effective enough, especially for female athletes (but then again, every anabolic steroid is.)

The fact that its bad side effect profile made it quite harmful to the athletes was irrelevant to the East German Communist regime. Many lives were destroyed, at least in the judgment of the unknowing female doping victims.

Why mention all this? First, this history has created a mystique, whether warranted or not. And second, it has provided us with a great deal of toxicological information. Last, one should be sure that if choosing the drug, the decision is not simply from the mystique. Being the old East German doping drug of choice should be irrelevant to whether an athlete or bodybuilder should choose it today. Instead it should be considered in terms of its positive and negative effects. Among available anabolic steroids, OT offers nothing outstanding here, though it’s certainly usable.

Dosing Of Oral Turinabol For Men

When Oral Turinabol is used in an anabolic steroid cycle, less than 20 mg per day will be an almost unnoticeable addition to a stack, or will be a very weak cycle if used alone. There is little point in exceeding 50 or 60 mg/day, as added anabolic effect will be small if any. And adverse side effects of excessive muscle pumps and/or blood pressure elevation are often at a tolerance limit at this point, while becoming excessive past it.

I don’t recommend combining OT with other oral anabolic steroids. Instead, when using OT and wishing to increase anabolism, one or more injectables should be added rather than another oral. A sufficient reason for this is that results are much better from combining an injectable rather than any other oral (with possible exception of oxandrolone.) Another reason is that at effective doses of OT, hepatotoxicity is already as high as can be considered reasonable. Another alkylated steroid should not be added.

Still another reason to not combine OT with other oral anabolic steroids in a stack with injectables is this: If Dianabol or Anadrol are included in the stack, then there’s no reason to also include OT. It will do nothing anabolically that they will not.

Oral Turinabol can be used alone with significant results for novice steroid users or for experienced users who have experienced losses and are regaining. However in general I don’t recommend oral only cycles, and this is no exception.

When using OT, dosing is preferably divided to twice per day, although once per day is acceptable.

Oral Turinabol For Women?

East German female athletes took OT at 5-15 mg per day for two to six weeks at a time. Aside from obvious virilization, many of these female athletes also suffered liver disease, heart disease, infertility, psychiatric issues, and even death. Oral Turinabol is proven not to be a safe anabolic steroid for women. I am not saying these consequences are inevitable, but rather that it’s a proven fact that the incidence rate of such consequences is very substantial.

Risk will exist for some women at doses less than 5 mg/day as well.

Nearly any anabolic steroid is better choice for women than OT.

Summary

Oral Turinabol is of interest mostly for its history, not its performance. When chosen, dosing range should be 20-60 mg/day, taken either once per day or preferably twice. It is usable by men, although there are better choices. OT is a very poor choice for women.

Oral Turinabol CAS: 2446-23-3

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2016年8月17日星期三

Cialis (Tadalifil)

Cialis (Tadalifil)

Cialis (Tadalafil) CAS: 171596-29-5


Cialis (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males.  Cialis works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function.  Cialis is much longer lasting than Viagra.  Effects can be felt anywhere between 36-48 hours.
Background
The FDA approved Cialis as a medicine for ED on November 21, 2003. It is available through prescription for those who are diagnosed with impotence.  In 1998, ICOS Corporation, and Eli Lilly and Company, began manufacturing Cialis, which is available orally in 5mg, 10mg and 20mg tablets.  It is also widely available by many research companies and underground labs.

Action
Tadalafil improves erectile function significantly, possibly increase testosterone through increased sexual activity, and is very safe.
There are limited side effects associated with its use.  The most common side effects are headache, upset stomach, back pain, and muscle aches, and usually subside with in a few hours.

Technical Data
In a six month study on men with erectile dysfunction ranging from mild to severe, 20 mgs of Cialis or placebo was administered to subjects as needed.  It was discovered that Tadalafil improved ED compared to placebo.  Ability to achieve erection and sucessful intercourse was 73% greater in those reciving Cialis verses the placebo group (1). Cialis was administered three times per week for an extended period of time, it was found to be extremely safe and very limited side effects were experienced, if any (1).
Cialis was also linked to increased testosterone levels in a one month study where testosterone levels were found to be significantly higher at the end of the month, due to increased sexual activity(2).

User Notes
How ironic. Some of the compounds which can be used to make men more physically attractive to women (Deca, Tren, etc…) can cause sexual dysfunction. Even more ironic is that many of the compounds which make them more attractive to us (Beer, Whiskey, etc…) can also do this.
Cialis is useful for these occasions…or during PCT when sexual dysfunction may occur.
Tadalifil citrate is the chemical name of active ingredient in Cialis. Cialis is a registered trademark of Lilly ICOS LLC in the United States and/or other countries.

References
1.A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men. Int J Clin Pract. 2005 Feb;59(2):143-9.
2.Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol (Oxf). 2004 Sep;61(3):382-6.



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How Does DNP Work for Fat Loss?

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DNP is a potentially FATAL compound to use. So do not take any potential use lightly. If you screw up, you will die. That said, here’s what DNP is.

DNP is what is termed a metabolic uncoupler meaning that it uncouples one metabolic process from another.

Specifically DNP blocks oxidative phosphorylation in the mitochondria of Type I muscle fibers. I bet that clears it right up. Ok, let’s take these words from the back to the front.

Type I muscle fibers: these are slow twitch muscle fibers used mostly for endurance events. They use mainly fat for fuel.

Mitochondria: these are the ‘powerhouses’ of the cell (in-joke for any physiology types since EVERY book I’ve ever read that mentions mitochondria has to comment that they are the powerhouses of the cell) which are involved in energy production, primarily through the breakdown of fat.

Oxidative phosphorylation: this is the chemical process by which the mitochondria makes ATP (adenosine triphosphate) in the cell. ATP is the only energy source that the body can use directly. When ATP is used, as during exercise, the body will make more ATP by breaking other stuff down (i.e. fat and carbohydrate).

So how does DNP work? DNP blocks the cell’s ability to produce ATP through oxidative phosphorylation. This causes the cell to become low in ATP. The cell doesn’t like being low in ATP so it tries to make more through oxidative phosphorylation (which breaks down fat for fuel). So it burns some fat in an attempt to make ATP. But it can’t, being blocked by DNP. So it burns some more fat in an attempt to make ATP. But it can’t. This continues as long as the DNP is in your system. End result: lots of fat burned in a futile attempt to make ATP.

But here’s the problem: energy is just heat. When the body breaks down fat to try to make ATP, some heat is generated. Since the ATP is never made (because of the DNP), the heat is dissipated out from the cell. Since fat continues to be burned (at very high rates) the body continues to produce more and more heat.

If you take too much DNP, your body will literally cook itself from the inside. it would not be a pleasant way to die. As an example, when I used DNP it was approximately 20 degrees outside (winter) and I still had to run a fan to keep cool. Nasty, nasty.

So that’s what DNP does.

As to your second question, thankfully DNP is not a supplement. It is legal (it is used to make bug spray because it cooks the bugs from the inside out) but the average person wouldn’t be able to get any (it can only be bought from chemical supply houses who typically don’t sell to individuals). And if you told anyone you were going to eat it, they’d think you were nuts.

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2016年8月16日星期二

Viagra: Uses, Health Benefits and Risks



Viagra: Uses, Health Benefits and Risks

Sildenafil Citrate (Viagra)  CAS: 171599-83-0

Viagra is one of the most controversial and widely talked about pharmaceutical drugs to have hit the market in the last 30 years.
The drug works well in most cases and has changed people's lives for the better.

In this article, we will look briefly at the history of Viagra, its pros and cons and anything to be wary of if you are considering its use.

What is Viagra?
Brief history of Viagra
Viagra dosage
Adverse events for Viagra
Other potential effects of Viagra
Sildenafil Citrate (Viagra)  CAS: 171599-83-0

Fast facts on Viagra

Here are some key points about Viagra. More detail and supporting information is in the main article.
Viagra was initially designed for hypertension and angina pectoris.
Viagra's main competitors are Cialis (tadalafil) and Levitra (vardenafil).
Side effects include headaches, hearing loss, impaired vision, increased intraocular pressure and dyspepsia.
Viagra pills are blue and diamond-shaped.
Individuals with kidney disease should not take Viagra.
Some athletes take Revatio in the belief that it enhances their performance.
Viagra works by inhibiting the enzyme cGMP-specific phosphodiesterase type 5.
Viagra was designed by Pfizer in Kent, England.
Some people use Viagra recreationally, although it is not thought to have any benefit in people without penile dysfunction.

What is Viagra?[Couple having sex]

Viagra was initially designed to help lower blood pressure but is now typically used to treat erectile dysfunction.Viagra is the brand name for sildenafil citrate, and is used for treating erectile dysfunction and pulmonary arterial hypertension. Originally developed by scientists in Great Britain, it was brought onto the market by Pfizer Inc., a US pharmaceutical company. Viagra is also sold under brand name Revatio.

Sildenafil citrate's chemical formula is C22H30N6O4S.

Viagra works by inhibiting an enzyme called cGMP-specific phosphodiesterase type 5, that delays degradation of cGMP, which controls blood flow in the penis. 

Brief history of Viagra

Viagra has become the prime treatment for impotence (erectile dysfunction), competing with Cialis (tadalafil) and Levitra (vardenafil) for market share.

Initially, the drug was designed by Pfizer scientists working in Kent, England. They were in fact working on a drug for hypertension (high blood pressure) and angina pectoris (a symptom of ischemic heart disease). 

During the phase I trials, it was noted that the drug did very little to prevent angina but did induce marked penile erections. Hitting the market in 1998, Viagra was the first oral treatment approved to treat erectile dysfunction in the US.

Viagra's meteoric rise to fame has seen it enter usage as an illicit drug. But, Viagra use in individuals without erectile dysfunction does not seem to have any effect. Although, researchers have noted that there is a significant placebo effect. On a similar note, there is no proven benefit for women taking the drug.

With endorsements from former US Senator Bob Dole and football star Pelé, the drug goes from strength to strength. In 2008, Viagra generated some $1.93 billion of revenue for Pfizer.

Dosage

Viagra, for erectile dysfunction, comes in blue, diamond-shaped pills, in doses of 25, 50, or 100 milligrams. The patient takes a maximum of one pill in a 24-hour period, between 30 minutes to 1 hour before sexual intercourse.

Revatio, for pulmonary arterial hypertension, comes in white, round, film-coated tablets. Patients take one 20 mg Revatio tablet three times a day.

Adverse events for Viagra 
According to clinical trial results, the most common side effects include headaches, nasal congestion, impaired vision, photophobia, and dyspepsia. Less commonly, some users have experienced cyanopsia (everything has a tinted blue tinge). 

In very rare cases, Viagra use can lead to vision impairment and nonarteritic anterior ischemic optic neuropathy. Postmarketing surveillance side effects have included (very rare) priapism, heart attack, sudden hearing loss, increased intraocular pressure, and ventricular arryhythmias. Since 2007, its labeling in the US has included a warning of the potential risk of sudden hearing loss.

Viagra can decrease blood supply to the optic nerve, causing sudden vision loss. This very rare adverse event occurred mainly to patients who had heart disease, hypertension, diabetes, high cholesterol, or pre-existing eye problems. Nobody really knows whether the vision loss was caused by the Viagra.

Interactions - HIV patients on protease inhibitors should discuss using Viagra with their doctors - protease inhibitors increase the likelihood and severity of side effects. Experts say such patients should have no more than 25mg, and not more often than every 48 hours.

If the patient is taking alpha blockers, they should make sure they take that medication and Viagra at least four hours apart, to prevent low blood pressure.

Contraindications - the following individuals should not take Viagra (or check with their doctors first):
Those on nitric oxide donors, nitrates and organic nitrites
Men who are advised to refrain from sexual intercourse because of cardiovascular risk factors
Patients with severe hepatic impairment
Patients with kidney disease
Individuals with low blood pressure (hypotension)
Those who have had a recent heart attack
Those who have had a recent stroke
Individuals with hereditary degenerative retinal disorders.

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2016年8月15日星期一

High Purity Raw Bodybuilding Steroids 360-70-3 Nandrolone Decanoate



Deca-Durabolin is a Nandrolone based steroid attached to the Decanoate ester with immense power due to its intrinsic properties. While there are many Nandrolone forms Nandrolone-Decanoate is the most common form among anabolic steroid users and it is the form known as Deca-Durabolin that most associate with the compound as that is the label name Organon gave its product. As Organon is one of the oldest and most respected human pharmaceutical companies all Nandrolone-Decanoate is commonly referred to as Deca-Durabolin. To fully understand this hormonal compound we only need to understand the active hormone Nandrolone and how the long ester Decanoate affects its release and mode of action. By understanding both aspects we can fully understand its benefits, how it effects the body and how best to supplement with use.
Deca-Durabolin is a 19-nor anabolic steroid based on the hormone Nandrolone which is a hormone found naturally in the human body, although in much smaller quantities when compared to other steroidal hormones of a similar class such as testosterone. Nandrolone is largely responsible for growth within the body as is evident as it was synthesized to treat severe cases of anemia. By supplementing with Deca-Durabolin we actively increase the amount of Nandrolone in our system thereby increasing growth of muscle tissue, as well as increasing hemoglobin and red blood cell count and nitrogen retention; all of which further lead to muscle tissue growth and regeneration. Nandrolone is a very powerful anabolic that does not convert to estrogen to a high degree as do many anabolic steroidal hormones but some conversion does exist.
As Deca-Durabolin is a Nandrolone attached to the Decanoate ester it is a very slow acting steroid but long lasting in effects. This particular steroidal compound carries with it a very long half-life of approximately 15 days; this is about as long as a half-life will ever be for an anabolic steroid with only Undecanoate ester based steroids being any longer. Because Deca-Durabolin is such a long ester based steroid the active hormone will not bring forth noticeable action for approximately 4 weeks after initial administration, however, because it is a long ester based hormonal compound its effects will stretch far past discontinuation of use.
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The Benefits of Deca-Durabolin
The benefits of Deca-Durabolin are very simple but as this is a very powerful anabolic they are very great. By understanding what Nandrolone does understanding the benefits of Deca-Durabolin should be fairly simple; increased muscle mass and increased strength. While these are the two most prominent effects there is the added benefit of joint relief as well by means of a secondary nature; for this reason many athletes will supplement with Deca-Durabolin even when not in a gaining phase in order to obtain such relief.
To give you an idea of how powerful this hormone is even small therapeutic doses can cause large increases in weight by increasing lean mass and this is achieved largely due to its nitrogen retention abilities. Those who supplement with Deca-Durabolin will find their muscle holds a far greater amount of nitrogen than without; as we understand being in a state of positive nitrogen retention is highly anabolic. This state of being can lead to vast although slow increases in muscle tissue and while that can lead to mass, coupled with increased collagen synthesis we experience a nice buildup in strength as well. Of equal importance if not even greater is the effect Nandrolone has on the production of IGF 1, a very powerful anabolic hormone in its own right belonging to the peptide class. While these potent anabolic qualities are very apt towards building mass and increasing strength they prove due to their action to readily promote a greater metabolic rate; this simply means we are able to build a larger, yet leaner and more powerful physique; as you can see Nandrolone is one amazing hormone.
The Side-Effects of Deca-Durabolin
All steroidal hormones carry with them possible negative side-effects, as do all medications, steroidal and non-steroidal alike; Deca-Durabolin makes no exception. By far the most prominent side-effect is testosterone suppression; while all anabolic steroids will suppress natural testosterone production to one degree or another Deca-Durabolin will do so in a far more pronounced manner. One dosing of this Nandrolone will result in complete testosterone suppression, even a very low dose will have this effect. For this reason it is very important to supplement with testosterone when we supplement with Deca-Durabolin; failure to do so will result in leaving the body completely testosterone deficient. Most will find a 2:1 ratio of Test:Deca to be sufficient but for some the need for testosterone to be slightly higher than this will prove to be a reality.
While this hormonal compound does not aromatize to high degree some aromatizing effects commonly associated with anabolic steroids can occur; while these are largely dose dependent ones sensitivity also comes into play. Further, when used for performance enhancing purposes these effects will assuredly be a reality as the dosing will necessarily be higher than simple therapeutic use in order to achieve a desired end result. Further, because Deca-Durabolin is a progestin by-which it will raise progesterone levels in the body, coupled with even a slight aromatase effect this can lead to Gynecomastia and excess water retention most commonly but this can easily be alleviated by the use of a quality aromatase inhibitor such as Arimidex or Letrozole.
Deca-Durabolin & Durabolin
As we now readily understand Deca-Durabolin is simply Nandrolone with the Decanoate ester attached and there are many other Nandrolone based steroidal compounds. While Deca-Durabolin is the most common and popular form Durabolin is a close second, especially in recent years. Durabolin is simple a Nandrolone hormone attached to the Phenylpropionate ester; a much shorter ester, thereby bringing benefit faster yet not as long lasting. The mode of action regarding the hormone Nandrolone does not change due to one form or the other being used; only the ester is different. Regardless of which form you use for each 100mg your apply, while Durabolin will provide slightly more active Nandrolone per mg than Deca-Durabolin due to the total mass of the Phenylpropionate ester being less than the Decanoate ester the difference is so slight it is meaningless; the same benefits are to be obtained with either form as the same active hormone is present in both. This is important because for years many misconceptions have led many to believe these two compounds differ greatly when the opposite is true. However, we must admit there is a slight difference as Durabolin or NPP as it’s commonly called seems to produce less water retention than its brother Deca-Durabolin.
Deca-Durabolin Cycles & Doses
Because it is so apt for strength and size most will use Deca-Durabolin during a bulking cycle; further, as water retention can be a problem when this steroid is used this makes periods of bulking or gaining the optimal time for use. However, as we’ve discussed excess water retention can be controlled through the use of a quality aromatase inhibitor and for this reason, as this is a powerful anabolic, many competitive bodybuilders will include Deca-Durabolin in their contest prep cycles. In most cases this will be done during the front end of the contest prep cycle in an effort to preserve muscle tissue and hold on to strength. However, many will run a low dose of the steroid almost the entire length of their contest prep in order to maintain joint comfort as discomfort can become quite serious when body-fat levels drop to very low levels.
For the majority, bulking will be the primary mode of use and as this is a very slow acting but long lasting steroid and as it is generally well-tolerated by most who use it, necessarily use will extend into several months if benefits are to be enjoyed. Generally Deca-Durabolin will need to be administered for at least 8 weeks with 12 weeks being optimal and 16 weeks being safe and highly effective for most individuals. Shorter duration will prove to be useless as it will take a good 4 weeks for the active benefits to begin to show making 4-6 week runs of the compound utterly useless. Most will find a dose of 200mg per week to be the minimum dosing to obtain benefits associated with growth, although a mere 100mg per week is often all that is used if joint relief is the primary concern. While 200mg is enough to spur growth most will find 400mg a week for approximately 12 weeks to be nearly a perfect dose and time frame for Deca-Durabolin use. Keep in mind, you must ensure you take enough testosterone with your Deca-Durabolin to ensure you keep enough active testosterone flowing in the body. For those who are looking for more of a bump 600mg per week can be successfully used, however, this is only recommended for those who have used the hormone before and understand how their bodies will react and how well they will tolerate this powerful Nandrolone; even so, many will find 400mg to be all they ever need regardless of how experienced they are.
Regardless of how much or for how long you supplement with Deca-Durabolin you will need to run a proper post cycle therapy (PCT) plan following use; failure to do so will result in continued suppression of your natural testosterone production. Further and of equal importance, because this is such a long acting steroid a proper PCT plan will and should not begin until at least 3 weeks have passed since your last injection of the hormone. For this reason, many steroid users will discontinue all Deca-Durabolin use a week or two before the total cycle ends in order to ease into a PCT more efficiently and sooner; the sooner we can enter PCT the greater the benefits we will enjoy as our recovery process begins sooner.
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